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RESEARCH PROJECTS
  1. The Building Blocks of Pregnancy Biobank This study established a longitudinal pregnancy biorepository at IUSM. Specimens are collected throughout pregnancy and at delivery and are paired with robust clinical outcome and covariate data. These specimens and data will serve as a resource for multiple studies analyzing the genetics and biomarkers for adverse pregnancy outcomes.
  2. The pharmacogenetics of antenatal corticosteroids This project examines genetic variation in pregnant women and newborns as a source of differences in neonatal response to steroids given to pregnant women to help mature the baby's lung more rapidly.
  3. Population pharmacokinetics, pharmacogenetics, and efficacy of SSRIs in pregnancy The amount or levels of some antidepressant medications in the blood (e.g. selective serotonin reuptake inhibitors or SSRIs) seems to be decreased during pregnancy. If the levels of SSRIs in the blood are low, the medication may not be adequately treating depression. The objective of our study is to evaluate whether pregnant women have decreased levels of SSRIs and a resultant decreased improvement of depression with SSRIs. We also want to evaluate whether variations in the genes related to how the body eliminates the SSRIs or how the SSRIs work influence the improvement in depression pregnant women get from these drugs.
  4. The pharmacokinetics and pharmacogenetics of nifedipine for preterm labor tocolysis The objective of this project is to characterize the blood concentrations or levels of nifedipine in pregnant women when used to help stop preterm labor. In addition, we will test for association between known genetic changes in the enzymes that metabolize nifedipine and other enzymes and transporters potentially involved in how women handle nifedipine and its efficacy during pregnancy.
  5. A pharmacogenetic study of vincristine neurotoxicity in pediatric patients with acute lymphoblastic leukemia This objective of this project is to identify genetic variations that predispose patients receiving vincristine chemotherapy to various toxicities and/or efficacy.
  6. A pediatric study of vincristine pharmacokinetics and pharmacogenetics in rhabdomyosarcoma patients This objective of this project is to identify genetic variations that predispose patients receiving vincristine chemotherapy to various toxicities and/or efficacy.
  7. Preterm Premature Rupture of Membranes: Erythromycin versus Azithromycin a randomized trial comparing their efficacy to prolong latency (PEACE trial) This randomized trial compares the most commonly used antibiotic regimens for women with PPROM, a leading cause of preterm birth.
PUBLICATIONS during course of the grant (7 in last year)
  1. Haas DM, Pazouki F, Smith RR, Fry AM, Podzielinski I, Al-Darei SM, Golichowski AM. Vaginal cleansing before cesarean delivery to reduce postoperative infectious morbidities: a randomized controlled trial. Am J Obstet Gynecol 2010; in press.
  2. Haas DM, Al Darei SM, Contreras K. Vaginal preparation with antiseptic solution before cesarean section for prevention of postoperative infections. Cochrane Database of Systematic Reviews, 2010, Issue 3.
  3. Haas DM. Preterm birth. BMJ Clin Evid 2010;01:1404 (PCMID-19450293)
  4. Haas DM, Hebert MF, Soldin OP, Flockhart DA, Madadi P, Nocon JJ, Chambers CD, Hankins GD, Clark S, Wisner KL, Li L, Renbarger JL, Learman LA. Pharmacotherapy and pregnancy: highlights from the Second International Conference for Individualized Pharmacotherapy in Pregnancy. Clin Transl Sci 2009;2:439-43.
  5. Broxmeyer HE, Cooper S, Hass DM, Hathaway JK, Stehman FB, Hangoc G. Experimental basis of cord blood transplantation. Bone Marrow Transplant 2009;44:627-33.
  6. Kochhar K, Saywell RM, Zollinger TW, Mandzuk CA, Haas DM, Howell LK, Sevilla Martir JF, Reger MK. Herbal remedy use among Hispanic women and Hispanic women with a history of pregnancy or breast feeding: are physicians informed? Hisp Health Care Int 2010, in press.
  7. Haas DM, Wunder K, Wolf JG, Denne SC. Women’s healthcare providers’ attitudes towards research in pregnancy. J Reprod Med 2010, in press.
  8. Haas DM, Imperiale, TF, Kirkpatrick PR, Klein RW, Zollinger TA, Golichowski AM. Tocolytic therapy: a meta-analysis and decision analysis. Obstet Gynecol 2009;113:585-94.
  9. Thompson PA, Rosner GL, Matthay KK, Moore TB, Bomgaars LR, Ellis KJ, Renbarger J, Berg SL. Impact of body composition on pharmacokinetics of doxorubicin in children: a Glaser Pediatric Research Network study. Cancer Chemotherapy and Pharmacology. 2009 Jul;64(2):243-51.
  10. Flockhart D, Skaar T, Berlin D, Klein T, Nguyen A Clinically available pharmacogemonics tests. Clin Pharmacol Ther. 2009 Apr 15 [Epub ahead of print]
  11. Haas DM, Renbarger JL, Denne S, Ahmed MS, Easterling T, Feibus K, Meslin EM, Koren G, Zajicek A, Snodgrass WR, Flockhart DA. Pharmacotherapy and pregnancy: highlights from the First International Conference for Individualized Pharmacotherapy in Pregnancy. Clinical Translational Science 2009;2:11-14.
  12. Dennison JB, Renbarger JL, Walterhouse, DO, Jones DR, Hall SD. Quantification of vincristine and its major metabolite in human plasma by high-performance liquid chromatography/tandem mass spectrometry. Ther Drug Monit. 2008 June 30(3):357-64.
  13. Haas DM, Ramsey PS. Progestogen for preventing miscarriage. Cochrane Database of Systematic Reviews 2008, Issue 2. Art. No.: CD003511
  14. Denne S, Harland J, Ellett M, Miller L, Hertz L, Thielking B, et al. Attitudes of Pediatric Health Care Professionals Toward Pediatric Biobanks. E-PAS 2008;260.
  15. Markel MK, Haut PR, Renbarger JL, Robertson KA, Goebel WS. Unrelated cord blood transplantation for severe congenital neutropenia: Report of two cases with very different transplant courses. Pediatric Transplantation. 2008 Dec;12(8):896-901.
  16. Haas DM, Renbarger JL, Meslin EM, Drabiak K, Flockhart D. Patient Attitudes Toward Genotyping in an Urban Women's Health Clinic. Obstet Gynecol 2008;112:1023-1028.
  17. Renbarger JL, McCammack KC, Rouse CE, Hall SD. Effect of race on vincristine-associated neurotoxicity in pediatric acute lymphoblastic leukemia patients. Pediatric Blood and Cancer. 2008 April;50(4):769-71.
  18. Haas DM. Letter to Editor. Preterm delivery and cytokine gene polymorphisms. J Reprod Med 2008;53:70
  19. Bernardi R, Bomgaars L, Fox E, Balis F, Egorin M, Lagattuta T, Aikin A, Witcomb P, Renbarger J, Lieberman F, Berg S, Blaney S. Phase I Clinical Trial of Intrathecal Gemcitabine in Patients with Neoplastic Meningitis. Cancer, Chemotherapy, and Pharmacology. 2008 July 62(2):355-61.